![]() It is our view that ‘dissociative’ experiences may well be instrumental in providing a more robust effect. No matter the route of administration, ketamine tends to produce dissociative effects in a broad range-almost none occurring in a session to strongly present– depending on dosage and your susceptibility. Hence, frequent sessions occur in the first 2-3 weeks. While more recent work has demonstrated the possibility of an anti-depressant response to low dosages of ketamine administered in different routes such as intravenous, intra muscular (IM,) intra-nasal and sublingual (in the mouth), this effect tends to be more sustained with repeated use-in other words, a cumulative effect. At the dosage level administered to you, you will most likely experience mild anesthetic, anxiolytic, antidepressant and, potentially, psychedelic effects. Ketamine is classified as a dissociative anesthetic, dissociation meaning a sense of disconnection from one’s ordinary reality and usual self. This is a very different pathway than that of other psychiatric drugs such as the SSRIs, SNRIS, lamotrigine, anti-psychotics, benzodiazepines, etc. ![]() How Does It Work? The current, most probable, understanding of ketamine’s mode of action is as an NMDA antagonist working through the glutamate neurotransmitter system. Ketamine is a Schedule III medication that has long been used safely as an anesthetic and analgesic agent and now, often effectively for treatment of depression, alcoholism, substance dependencies, PTSD and other psychiatric diagnoses as well as for existential, psychological and spiritual crises and growth. Ketamine is now an “off-label” treatment for various chronic “treatment-resistant” mental conditions. ![]() Information for Your Understanding of the KAP Process Introduction
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